At a glance
Presentation: Cream · daily
Strength / amount: Bioidentical
Price: From $169/month
Billing: Billed monthly. Cancel anytime.
Estradiol cream is a bioidentical hormone therapy applied to the skin to help relieve symptoms tied to declining estrogen during perimenopause and postmenopause. Estradiol is absorbed through the skin into the bloodstream, which many clinicians prefer over oral estrogen because it bypasses the liver. The cream offers flexibility in where and how it is applied. It is prepared by a state-licensed compounding pharmacy on your clinician's prescription.
What it can help with
- Hot flashes and night sweats — may help reduce their frequency and intensity
- Sleep and mood — may support sleep quality and emotional steadiness through the menopausal transition
- Vaginal dryness and discomfort — may relieve the genitourinary symptoms of menopause
- Bone health — estradiol therapy is widely recognized for supporting bone density in postmenopausal patients
What to expect
Symptom relief usually begins within a few weeks, with fuller benefit over 2 to 3 months. The dose is personalized and can be adjusted over time. Individual results vary and are not guaranteed.
How it works
How to use it: Apply a small measured amount to clean, dry skin once a day (inner thighs, inner arms, or abdomen are common sites). Let it absorb completely before dressing or having contact with other people, since estradiol can transfer through skin contact.
How to start: Place your order and complete a brief online medical intake. A licensed clinician reviews your history to determine whether the treatment is appropriate for you. In some states a short telehealth appointment may be required (at no additional cost) before a prescription is issued. If approved, your treatment is prepared by a state-licensed pharmacy and shipped discreetly to your door. Most clients receive their first order within a week.
After your first delivery, a new supply arrives automatically every 4 weeks — no reordering needed. You can delay a shipment or cancel anytime from your account.
Your dose: Personalized by your clinician and adjusted over time based on how your body responds to treatment and how your health needs change.
Important to know
- Estradiol cream is a prescription medication and requires evaluation by a licensed clinician.
- It is compounded by a state-licensed pharmacy and is not FDA-approved as a finished product; FDA-approved brand products also exist.
- Patients with an intact uterus usually take progesterone alongside estradiol to protect the uterine lining. Progesterone is available as a separate product.
- Hormone therapy is not for everyone. Individual results vary and are not guaranteed.
Prescription treatment. Eligibility, dose, contraindications, monitoring, and follow-up are determined by the licensed clinician. Product availability and fulfillment may vary.
